Research Associate I/II, Analytical Development

As a Research Associate I/II at Lexeo Therapeutics, your main responsibilities will include supporting the development of analytical assays for AAV-based gene therapy. You’ll perform cell-based and molecular assays, assist in laboratory operations, and collaborate with senior scientists to solve challenges. Additionally, you'll maintain cell lines, contribute to organizing analytical capabilities, and participate in routine lab activities, ensuring alignment with research protocols and FDA regulations.

To qualify for the Research Associate I/II role at Lexeo Therapeutics, candidates must hold a Bachelor's degree in chemistry, biochemistry, life sciences, or a related field, with 0 to 3 years of relevant experience. Hands-on experience in cell and gene therapy is highly desirable. Familiarity with analytical assay development and an understanding of FDA regulations and cGMPs will also be advantageous.

Successful candidates for the Research Associate I/II position at Lexeo Therapeutics should possess strong organizational and problem-solving skills, excellent communication abilities, and a proactive team-oriented attitude. Familiarity with electronic laboratory notebooks and a capability to manage multiple tasks in a fast-paced environment are also essential for success in this role.

At Lexeo Therapeutics, Research Associates I/II can expect a hybrid work environment that combines both in-office days in New York City and remote work options. This flexible work culture is designed to support a diverse range of candidates while fostering collaboration and innovation within the team.

Lexeo Therapeutics encourages career growth for Research Associates I/II through continuous collaborative learning, mentorship from senior scientists, and participation in cutting-edge research projects. By providing opportunities for professional development and access to the latest advancements in gene therapy, Lexeo ensures that employees can enhance their skills and advance their careers in the biotech industry.

The salary range for the Research Associate I/II position at Lexeo Therapeutics is competitive, typically between $65,000 to $85,000 annually. The specific salary offered will depend on the qualifications and overall experience of the candidate, promising a fair compensation in line with industry standards.

A Research Associate I/II at Lexeo Therapeutics will perform a variety of assays, including digital PCR, ELISA, and in vitro analytical assays tailored for AAV gene therapy vectors. These methodologies are crucial for the development and validation of therapeutic products in the lab.

When discussing your experience with molecular and cell-based assays, focus on specific techniques you've used, such as qPCR or ddPCR. Highlight any relevant projects, your contribution to data analysis, and how these experiences helped you understand assay development and troubleshooting in a laboratory setting.

To effectively prioritize tasks, demonstrate how you assess urgency versus importance and describe a system or method you employ to stay organized. Share an example of a time when you successfully managed multiple tasks, ensuring all deadlines were met while maintaining quality.

When asked about FDA regulations and cGMPs, show your understanding of what they mean for laboratory practices. Mention familiarity with guidelines that help ensure product safety and quality, as well as any experience you have adhering to these standards in past roles.

In your answer, emphasize the importance of collaboration in research. Provide a specific example where teamwork led to a successful experiment or solution to a problem, detailing your involvement and the skills you utilized to foster communication and cooperation.

Discuss the importance of accurate data documentation, mentioning any specific tools you’ve used, such as electronic laboratory notebooks like Benchling. Provide examples of your data management practices, such as regular updates, thorough protocols, and checks for compliance with scientific standards.

When asked about troubleshooting, detail your systematic approach to identifying problems in assays, such as reviewing protocols, analyzing controls, and consulting with lab colleagues. Share an experience where your troubleshooting led to improved assay performance or data integrity.

Handling feedback positively is crucial in research. Discuss your approach to receiving constructive criticism, implementing suggestions, and learning from the experience. Share an example of a time when feedback enhanced your work or project outcomes.

Express your genuine interest in Lexeo Therapeutics and their mission to transform healthcare with gene therapy. Mention specific aspects of their research that excite you, such as innovative projects, company culture, and potential impacts on patient outcomes, showing your alignment with their goals.

Your answer should reflect a solid understanding of gene therapy, highlighting its potential to address genetic disorders and its revolutionary impact on treatment methodologies. Discuss recent advancements or projects in the field, referencing Lexeo Therapeutics’ work and how it contributes to the innovation landscape.

When discussing your experience with laboratory equipment, be specific about the tools you’ve used, such as PCR machines, cell culture equipment, or analytical balances. Mention your proficiency, any training received, and how this hands-on experience equips you to contribute effectively at Lexeo Therapeutics.