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Scientist III

About IGM Biosciences, Inc.


IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company committed to developing and delivering a new class of medicines to treat patients with autoimmune and inflammatory diseases. The Company’s pipeline of clinical and preclinical assets is based on the IgM antibody, which has 10 binding sites, compared to conventional IgG antibodies with only 2 binding sites. We have created unique IgM antibodies with high selectivity, affinity, and avidity that may redefine what is possible for therapeutic antibody medicines. We are committed to exploring how the unique structure and binding properties of the IGM antibody can improve outcomes for patients with these serious conditions. The Company also has an exclusive worldwide collaboration agreement with Sanofi to create, develop, manufacture, and commercialize IgM antibody agonists against oncology, immunology, and inflammation targets. For more information, please visit www.igmbio.com.

 

Imvotamab in Autoimmune and Inflammatory Diseases

Imvotamab is a bispecific T cell engaging IgM antibody targeting CD20 and CD3 proteins. We believe that Imvotamab, with its 10 binding units for CD20, may successfully bind to CD20 expressing B cells with more power (avidity) compared to an IgG bispecific antibody with only one or two binding units for CD20. Our preclinical studies suggest that Imvotamab may offer the potential for deeper depletion of B cells, including those in low CD20 expressing cells, than currently approved antibody therapies. We are evaluating Imvotamab in Phase 1b clinical trials of Imvotamab in severe systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and idiopathic inflammatory myopathies (myositis).


Position:

We seek a highly motivated and innovative scientist with immunology research experience and a passion to develop antibody-based therapeutics. You will play an integral role in the pre-clinical development of novel autoimmunity and inflammation therapeutics. The ideal candidate will have a proven track record of experience with core immunological assays and models (e.g., T cell proliferation, antigen recall, in vivo models of inflammatory disease) and techniques (immune cell culture, flow cytometry, ELISA, RT-PCR, etc.) The candidate will be required to coordinate and execute on research projects across multiple functional teams, both internal of IGMS and external vendors and collaborators. Strong communication skills and organizational skills are essential. A key initial responsibility will be the set up and establishment of core capabilities in the AI lab. This role involves delivering on programs through proof- of-concept in vitro and in vivo studies and advancing therapeutic candidates from early discovery to IND- enabling studies. 


Responsibilities:
  • Establish core capabilities in AI lab
  • Lead research efforts to generate proof-of-concept in vitro and in vivo data for early-stage autoimmune and inflammation programs
  • Lead therapeutic candidate selection and perform IND-enabling studies
  • Work closely with team members and CROs to develop assays and models to assess biological activity
  • Present results at internal and external meetings


Qualifications:
  • Ph.D. with 2-7 years of industry experience or with equivalent postdoctoral research experience or a Bachelor’s/ Master’s degree with 10+ years of industry experience in the field of immunology.
  • Must have hands-on experience and proficiency in one or more of the following areas: multi-color flow cytometry, complex cell-based functional assays, in vivo mouse models of disease.
  • Must be proficient with Microsoft Word, Excel, and PowerPoint, GraphPad Prism, and FlowJo.
  • Experience establishing mechanistic in vitro and ex vivo immune cell-based assays with primary immune cells from human and relevant animal species.
  • Understanding of and ability to select relevant in vivo models for mechanistic and efficacy studies.
  • Demonstrated track record of independence, critical thinking, and scientific research achievements in immunology and/or significant contributions to a discovery program or therapeutic development.
  • Highly organized with reliable time-keeping skills and able to maintain a detailed and wellorganized electronic notebook.
  • Must have strong interpersonal, collaboration, and communication skills.
  • Being a team player and respectful of others is a must.
  • Able to thrive in a fast-paced, start-up environment.
  • Able to commute to Doylestown. 


$128,000 - $160,000 a year
This range reflects the job's characteristics, such as required skills and qualifications, and is based on the office location noted in this job posting. The range may also be adjusted based on the applicant's geographic location.

Actual individual pay is determined by demonstrated experience and internal equity alignment.

We offer a fast-paced, collaborative, team-based work environment. 

 

One of our top priorities is to maintain our employees' and their families' health and well-being. To achieve this goal, we offer comprehensive benefits with a variety of options:


Medical, dental, and vision insurance.

IGM covers the full premium amount for our employees and their dependents

FSA (Flexible Spending Account) or HSA (Health Savings Account)

STD, LTD, Basic Life and AD&D Insurance, Supplemental Life and AD&D Insurance

Voluntary Life Insurance and Disability

401(k) Plan with Employer Match

3 Weeks of Paid Time Off, 5 sick days per year, 12 holidays

Cell phone & internet subsidy

Employee Referral Bonus Program

Annual training budget for professional development

Commuter Benefit

Pet Insurance

Annual bonus program

New hire equity

Annual refresh grants

ESPP (Employee Stock Purchase Plan)

 

IGM is an equal opportunity employer that prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will be considered for employment.

Average salary estimate

$144000 / YEARLY (est.)
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$128000K
$160000K

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What You Should Know About Scientist III, IGM Biosciences, Inc.

Join IGM Biosciences as a Scientist III in Doylestown, PA, where your innovative spirit and immunology expertise will be at the forefront of advancing novel therapeutics targeting autoimmune and inflammatory diseases. At IGM, we pride ourselves on developing unique IgM antibodies with exceptional binding capabilities, and as a Scientist III, you'll play a key role in this endeavor. Your responsibilities will include establishing core capabilities within our AI lab and leading research efforts to generate proof-of-concept data through in vitro and in vivo studies. Collaborating with cross-functional teams, you'll help guide therapeutic candidate selection and conduct IND-enabling studies, pushing the boundaries of current treatments available in the market. We’re seeking someone with a Ph.D. or equivalent hands-on experience in immunology or a related field. If you’re adept in core techniques, including flow cytometry, cell culture, and immune assays, and have strong organizational and communication skills, this is the perfect opportunity to contribute to cutting-edge research while making meaningful impacts on patient outcomes. Embrace the chance to work in a dynamic and supportive environment, where your contributions fuel collaborative success and innovation every day. With competitive compensation and comprehensive benefits, IGM Biosciences is dedicated to fostering your career growth while ensuring the well-being of our employees and their families.

Frequently Asked Questions (FAQs) for Scientist III Role at IGM Biosciences, Inc.
What qualifications are required for the Scientist III position at IGM Biosciences?

To qualify for the Scientist III role at IGM Biosciences, candidates should ideally hold a Ph.D. with 2-7 years of industry experience or a Bachelor’s/Master’s degree with 10+ years of relevant experience in immunology. Proven hands-on expertise in core immunological techniques and assays is essential. Strong organizational and communication skills are also required to excel in this collaborative environment.

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What kind of work environment can I expect as a Scientist III at IGM Biosciences?

As a Scientist III at IGM Biosciences, you can expect a fast-paced, collaborative, and supportive work environment. The company values teamwork and innovation and is committed to fostering a culture that encourages scientific exploration and personal growth while maintaining a focus on employees' well-being.

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What will my primary responsibilities be in the Scientist III role at IGM Biosciences?

In the Scientist III position at IGM Biosciences, your primary responsibilities will include establishing core capabilities within the AI lab, leading research efforts to generate proof-of-concept data, and collaborating closely with team members and external partners to advance therapeutic candidates through IND-enabling studies. Your expertise will be crucial in driving innovative therapies forward.

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Is prior experience with antibody therapeutics necessary for the Scientist III position at IGM Biosciences?

Yes, prior experience with antibody therapeutics is highly beneficial for the Scientist III role at IGM Biosciences. Candidates should have a solid background in immunology and familiarity with developing and evaluating antibody-based therapies to be successful in this position.

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What skills are essential for success in the Scientist III role at IGM Biosciences?

Success in the Scientist III role at IGM Biosciences demands strong skills in immunological techniques such as multi-color flow cytometry, cell-based functional assays, and in vivo models. Critical thinking, independent research abilities, and effective communication across teams are equally vital to thrive in this collaborative setting.

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What kind of research projects will I be involved in as a Scientist III at IGM Biosciences?

As a Scientist III at IGM Biosciences, you will be involved in exciting pre-clinical research projects focusing on developing novel antibody-based therapeutics for autoimmune and inflammatory diseases. Your role will involve generating in vitro and in vivo data, leading assay development, and contributing to advanced therapeutic candidate selections.

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What benefits does IGM Biosciences offer to its employees?

IGM Biosciences offers a comprehensive benefits package, including medical, dental, and vision insurance, paid time off, a 401(k) plan with employer match, professional development budgets, pet insurance, and stock options. These are designed to promote the health and well-being of employees and their families.

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Common Interview Questions for Scientist III
Can you explain your experience with multi-color flow cytometry?

When discussing your experience with multi-color flow cytometry, be sure to highlight specific projects where you've successfully implemented this technique. Describe how you prepared samples, your approach to data analysis, and the insights gained that contributed to the research objectives. Mention any challenges faced and how you overcame them to demonstrate your problem-solving skills.

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How do you stay current with advancements in immunology research?

To convey how you stay current with advancements in immunology research, share your strategies such as regularly reading peer-reviewed journals, attending conferences, and participating in professional networks. Highlight any specific methodologies or findings that you've integrated into your work as a result of this continuous learning.

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Describe a time when you had to collaborate with a cross-functional team.

When answering this question, choose an example that showcases your teamwork abilities. Outline the project goals, your role within the team, and how you effectively communicated with team members from different departments. Focus on the outcomes and any innovative solutions that emerged from the collaboration.

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What strategies do you use to establish core assay capabilities?

Discuss specific strategies you've employed to establish core assay capabilities in previous roles. Highlight elements like systematic planning, resource allocation, team training, and validation of protocols. Emphasize your attention to detail and how you ensure reproducibility and reliability in the assays developed.

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Can you provide an example of a challenging project and how you handled it?

Select a project that posed significant challenges and describe the problems faced, what steps you took to address them, and the final outcomes. Be sure to convey your problem-solving skills and resilience, demonstrating your capacity to thrive in a fast-paced research environment.

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What is your approach to presenting research findings to diverse audiences?

When discussing your approach to presenting research findings, detail how you tailor your presentations based on the audience's knowledge level. Emphasize the importance of clarity, storytelling, and engaging visuals, while also mentioning how you prepare for questions and discussions during these presentations.

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How would you lead a research effort in a new area of therapeutics?

In answering, outline your methodology for leading a new research initiative, such as conducting thorough literature reviews, assembling a knowledgeable team, establishing clear milestones, and fostering communication among team members. Stress the importance of adaptability and continuous reassessment of strategies as research progresses.

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What techniques do you prefer for developing in vivo models?

When answering this question, provide specific examples of in vivo models you have developed or worked with, detailing your rationale for selecting those models. Address any challenges encountered during development and how they were overcome, as well as the models’ relevance to your studies.

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What is your experience with data analysis software relevant to immunology?

Highlight your proficiency with data analysis software such as GraphPad Prism or FlowJo. Provide examples of how you’ve used these tools to interpret complex datasets generated from experiments. Discuss how your analytical skills have aided in drawing meaningful conclusions that furthered project goals.

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Why do you want to work at IGM Biosciences as a Scientist III?

When answering this question, express your passion for advancing therapeutic solutions for autoimmune and inflammatory diseases, and how IGM Biosciences' innovative approach aligns with your career goals. Mention specific aspects of the company's research focus or values that resonate with you and your desire to contribute to a collaborative research environment.

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About IGM Biosciences: Headquartered in Mountain View, California, IGM Biosciences is a clinical-stage biotechnology company focused on creating and developing IgM antibodies. IGM Biosciences has worked to overcome the manufacturing and protein en...

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DATE POSTED
November 25, 2024

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