Process Engineering Intern (25300-T-680-PS)

WHO WE ARE

Arsenal Biosciences Inc. is a clinical stage programmable cell therapy company engineering advanced CAR T-cell therapies for solid tumors. We are seeking a motivated and talented intern to join the ArsenalBio Process Engineering team. This role is an onsite position located at our Hayward office. 

ArsenalBio’s mission and purpose is very clear: defeat cancer. With our programmable and computationally driven approach, our team is engineering medicines with the goal to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.

Driven by a collective of diverse experts across multi-scientific disciplines as well as clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.

This means you’ll have the opportunity to work with the best talent in the field of cell therapy, and be part of ONE TEAM advancing therapies for patients who need it most.

The successful candidate will work closely with cross-functional team members to develop and optimize phase-appropriate, GMP-compatible manufacturing processes and procedures for our clinical stage cell therapy products. This individual will be responsible for  the execution and documentation of Drug Product (DP) process characterization studies (e.g. fill volume range finding, post-thaw stability evaluations, thaw recovery assessments) as well as preparation of data sets that will ultimately contribute to regulatory filings. This position will report into a Senior Process Engineer within the Process Engineering team, and will also interact cross-functionally within Process Sciences (e.g. Process Development, Analytical Development), Tech Ops (e.g. Manufacturing, Supply Chain, Quality), and across the organization (e.g. Clinical Subteam) to enable the success of ArsenalBio.

• Plan, execute, analyze, and report on experiments and analytic assays to support the development, process characterization, and process validation of drug product GMP process to manufacture, characterize, and release T cell therapy products
• Execute in-process, product, and in-use T cell stability studies using various candidate drug product container configurations to enable various clinical dose levels
• Execute cryopreservation characterization studies to optimize thermal load distribution and ensure product stability during crucial cryopreservation unit operations
• Evaluate secondary and tertiary Drug Product container configurations to develop and optimize end-to-end drug product transportation and delivery strategy
• Collaborate closely with other functions to enable effective and successful project execution
• Actively engage in cross-functional collaboration with peers
• Organize, communicate, and present data to key stakeholders
• Assist cross-functional activities including hand-offs to various teams, compiling data, and presenting at technical meetings

• Opportunity to gain experience working in an industry BSL 2 lab environment with specialized cell therapy processing equipment 
• Opportunity to learn about and execute flow cytometry assays to characterize cell product quality prior to and after cryopreservation
• Opportunity to gain familiarity with the drug product development lifecycle and clinical trial design and execution from a trial sponsor perspective
• Opportunity to learn about GMP process design principles and use of engineering and process controls in order to maintain drug product quality
• Opportunity to learn about and provide input on logistical considerations for shipping drug product to trial centers while introducing sufficient controls to ensure product quality 

• Current 3rd or 4th year undergraduate student enrolled in a Bachelors degree program studying Biology, Biochemistry and Molecular Biology, Immunology, or similarly relevant degree program
• Experience working in a biological laboratory setting with basic lab techniques (e.g. use of PPE, pipetting, centrifuge balancing, lab notebook documentation, aseptic technique) is required
• Ability to quickly adapt and learn new skills for changing research priorities
• Flexible mind with the ability to think outside the box, creative approach to problem-solving
• Demonstrated ability to work well in a highly collaborative team environment, coordinate tasks across multiple projects to meet deadlines
• Willingness to accept other responsibilities outside of initial job description

• Experience with human immune cell isolation, T cell expansion, and mammalian cell culture techniques is desirable
• Knowledge of cell therapy and/or gene therapy is desirable
• Experience with data visualization software (e.g. JMP, Prism, Tableau) is a plus
• Familiarity with/knowledge of biological assays (PCR, Flow Cytometry, Cytokine ELISA) is a plus

BENEFITS AND PAY

Our people-first culture fosters a deep appreciation for humanity, both in the people we endeavor to serve as well as each other. We are proud to work for a company that is driven by diversity in experiences, ideas and interests, and one that empowers us in an environment that embraces both unity and inclusivity.

We have robust tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as our people are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

The estimated base salary for the preferred primary location of the San Francisco Bay area ranges from $25.00–$30.00/hour. Salary ranges for other locations may vary.  Base pay offered may vary based on job related knowledge, experience, education, and location.  In addition to these factors, we believe in the importance of pay equity and consider internal equity of our current employees as part of any final offer.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.