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Principal/Director, Medicinal Chemistry

About Us


We are looking for dedicated professionals who thrive on tackling complex challenges and are committed to improving the lives of patients. If you value innovation, collaboration, and integrity, and are eager to contribute to advancing therapies for renal diseases, we encourage you to join our team. Based in the state-of-the-art Bakar Labs in Berkeley, CA, we are focused on pioneering medicines that make a meaningful impact.


About the Role


Renasant Bio is seeking a self-motivated medicinal chemistry leader capable of driving projects from hit generation through development candidate selection in a startup environment. The candidate should be a self-motivated and influential leader with a strong record of accomplishment in medicinal chemistry and CRO (Contract Research Organization) oversight.


This newly created role will report directly to our Senior Vice President, Chemistry.


What You'll Do
  • Apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs from hit finding to development candidate selection or series go/no go decisions
  • Contribute to setting the overall drug discovery strategy and long-term pipeline development
  • Present the rationale, strategy, and updates of the program chemistry efforts to scientists in other disciplines
  • Drive design efforts; understand standard medicinal chemistry computational tools and can integrate the information from these tools into the design and evaluation of proposed targets
  • Manage chemistry CROs; demonstrate good strategic thinking in allocating resources and prioritizing series
  • Reduce ideas to practice quickly, optimize the design, make, test, analysis cycle
  • Maintain an excellent record, including updating our data warehouse
  • Contribute effectively to patent, report, and scientific publication writing


What You'll Bring
  • PhD in organic chemistry or related fields with 7+ years of experience in pharmaceutical / biotech setting.
  • Team player with strong organizational and interpersonal skills. Experience functioning in a multidisciplinary, dynamic and highly matrixed environment
  • Effectively collaborate with scientists/ teammates with diverse background
  • Demonstrate a strong command of basic biology, pharmacology, ADME issues, and series SAR
  • Strong track record of problem-solving skills and scientific creativity in synthetic and medicinal chemistry as evidenced by a significant publication record, filed patents and presentations.
  • Excellent written and oral communication skills
  • Prior experience successfully leading phenotypic projects from hit finding to development candidate selection would be a plus
  • Prior experience in chemical biology, target deconvolutions strategies would a plus


We believe in building balanced teams. We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.

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What You Should Know About Principal/Director, Medicinal Chemistry, 5AM Ventures

Are you ready to make a significant impact in the field of medicinal chemistry? Renasant Bio is on the lookout for a Principal/Director of Medicinal Chemistry to join our vibrant team in the Bay Area, CA. At Renasant Bio, we’re passionate about creating innovative therapies that improve the lives of patients facing renal diseases. Our state-of-the-art Bakar Labs in Berkeley serves as the perfect backdrop for those who thrive in a collaborative environment. In this role, you will lead projects from hit generation all the way to development candidate selection, providing your expertise in medicinal chemistry and overseeing CRO collaborations. Your strategic thinking will play a pivotal role in shaping our drug discovery strategy and developing our long-term pipeline. If you enjoy working in a multidisciplinary, dynamic space and have a strong track record in pharmaceutical or biotech settings, you're a perfect fit for our team. You'll also get the chance to engage with various teams, present your insights, manage resources effectively, and contribute to scientific writing. If you have a PhD in organic chemistry and at least 7 years of relevant experience under your belt, come connect with us. Together, let's innovate and change lives one therapeutic at a time!

Frequently Asked Questions (FAQs) for Principal/Director, Medicinal Chemistry Role at 5AM Ventures
What responsibilities come with the Principal/Director, Medicinal Chemistry role at Renasant Bio?

The Principal/Director of Medicinal Chemistry at Renasant Bio will be responsible for leading medicinal chemistry initiatives from hit generation through to development candidate selection, setting drug discovery strategies, overseeing CRO collaborations, and presenting program updates to multidisciplinary teams.

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What qualifications do I need for the Principal/Director, Medicinal Chemistry position at Renasant Bio?

To qualify for the Principal/Director, Medicinal Chemistry role at Renasant Bio, candidates should possess a PhD in organic chemistry or a related field, along with at least 7 years of experience in pharmaceutical or biotech environments.

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Is prior experience in CRO management important for the Principal/Director, Medicinal Chemistry at Renasant Bio?

Yes, prior experience in managing Contract Research Organizations (CROs) is critical for the Principal/Director, Medicinal Chemistry role at Renasant Bio, as you will be responsible for strategic resource allocation and prioritizing project series.

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What career growth opportunities exist for the Principal/Director, Medicinal Chemistry at Renasant Bio?

Renasant Bio provides a highly collaborative environment that offers opportunities for career advancement, professional development, and the chance to work on groundbreaking therapies. You'll have room to influence drug discovery strategies and contribute to innovative solutions.

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What skills are essential for success as a Principal/Director, Medicinal Chemistry at Renasant Bio?

Essential skills include a strong command of medicinal chemistry principles, problem-solving abilities, excellent communication skills, and the capacity to work in a multidisciplinary environment, all of which are critical for the Principal/Director, Medicinal Chemistry position at Renasant Bio.

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What types of projects will the Principal/Director, Medicinal Chemistry be working on at Renasant Bio?

The Principal/Director, Medicinal Chemistry will work on projects related to developing therapies for renal diseases, overseeing the drug design process from hit finding to selection of development candidates and contributing to patent writing and publications.

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How does Renasant Bio foster a collaborative work environment for the Principal/Director, Medicinal Chemistry?

Renasant Bio promotes collaboration through cross-disciplinary teamwork, where the Principal/Director, Medicinal Chemistry engages with diverse scientists, contributes to shared goals, and actively participates in strategic discussions within a supportive environment.

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Common Interview Questions for Principal/Director, Medicinal Chemistry
Can you describe your experience with driving projects from hit generation to development candidate selection?

When discussing your experience, focus on specific projects where you played a key role in each phase of development, including any challenges you faced and how you overcame them. Emphasize your strategic input and collaborative efforts with cross-functional teams.

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How do you manage CRO relationships effectively in the medicinal chemistry field?

Highlight your approach to communication and collaboration, sharing examples of how you’ve ensured alignment on project goals, optimally allocated resources, and maintained quality controls while working with CROs.

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What is your process for evaluating drug design proposals?

Articulate your methodical approach, including how you leverage computational tools, review literature precedents, and assess the feasibility and potential of drug targets. Provide examples of past evaluations that led you to successful outcomes.

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How do you stay current with advancements in medicinal chemistry?

Discuss the journals, workshops, and online courses you follow or participate in. Additionally, mention your involvement in professional networks or research collaborations that keep you updated on trends and breakthroughs in the field.

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Can you share an example of a significant publication or patent you contributed to?

Choose a publication or patent that aligns with your passion for innovative therapies. Summarize your contributions, the research impact, and any challenges faced during the process, demonstrating your scientific creativity.

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Describe a time when you had to solve a complex problem in medicinal chemistry.

Think of a specific challenge you encountered and walk through the problem-solving process you implemented. Emphasize teamwork, critical thinking, and the innovative solutions you developed to resolve the issue.

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What strategies do you use for mentoring junior chemists?

Discuss your philosophy on mentorship, highlighting ways you provide guidance, share knowledge, and foster a collaborative learning environment. Mention specific instances where you helped junior chemists grow their skills.

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How do you balance multiple ongoing projects while ensuring quality outcomes?

Explain your organizational techniques and prioritization strategies. Provide examples of how you've managed competing timelines without compromising on quality, focusing on communication methods with your team.

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In your opinion, what is the future of medicinal chemistry in biotech?

Share your insights about emerging trends, technologies, and challenges in medicinal chemistry. Discuss your vision for how these elements shape future advancements and how you can contribute to this evolution at Renasant Bio.

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What role does collaboration play in your work as a medicinal chemist?

Emphasize the importance of collaboration with diverse teams in driving successful projects. Use examples of how teamwork has led to innovative solutions and effective problem-solving in your past research experiences.

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Full-time, on-site
DATE POSTED
November 28, 2024

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